{"id":3842,"date":"2024-10-01T17:15:44","date_gmt":"2024-10-01T15:15:44","guid":{"rendered":"https:\/\/amsbiopharma.com\/analysis-of-protein-based-pharmaceuticals\/"},"modified":"2026-09-23T15:06:26","modified_gmt":"2026-09-23T13:06:26","slug":"analisis-de-biofarmaceuticos-basados-en-proteinas","status":"publish","type":"page","link":"https:\/\/amsbiopharma.com\/es\/analisis-de-biofarmaceuticos-basados-en-proteinas\/","title":{"rendered":"An\u00e1lisis de P\u00e9ptidos y Amino\u00e1cidos\/ NO GLP"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"3842\" class=\"elementor elementor-3842 elementor-518\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-173d0485 e-flex e-con-boxed e-con e-parent\" data-id=\"173d0485\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-12f5c589 e-con-full e-flex e-con e-child\" data-id=\"12f5c589\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-404c2629 e-con-full e-flex e-con e-child\" data-id=\"404c2629\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3d5dbd21 elementor-widget elementor-widget-heading\" data-id=\"3d5dbd21\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">An\u00e1lisis de P\u00e9ptidos y Amino\u00e1cidos<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-79488fdb e-con-full e-flex e-con e-child\" data-id=\"79488fdb\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-345470b8 elementor-widget elementor-widget-text-editor\" data-id=\"345470b8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Servicios anal\u00edticos validados para p\u00e9ptidos terap\u00e9uticos, amino\u00e1cidos y terap\u00e9uticos sint\u00e9ticos basados en p\u00e9ptidos en todas las fases de desarrollo.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b1f5714 e-con-full e-flex e-con e-child\" data-id=\"b1f5714\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;video&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-f6ea168 e-con-full e-flex e-con e-child\" data-id=\"f6ea168\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;video&quot;,&quot;background_video_link&quot;:&quot;https:\\\/\\\/amsbiopharma.com\\\/wp-content\\\/uploads\\\/Clip5_Analysis_Protein_Based_Biofarmaceuticals_SM.mp4&quot;,&quot;background_play_on_mobile&quot;:&quot;yes&quot;,&quot;background_video_start&quot;:0,&quot;background_video_end&quot;:8,&quot;background_play_once&quot;:&quot;yes&quot;}\">\n\t\t<div class=\"elementor-background-video-container\">\n\t\t\t\t\t\t\t<video class=\"elementor-background-video-hosted\" role=\"presentation\" autoplay muted playsinline><\/video>\n\t\t\t\t\t<\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3731f06 e-flex e-con-boxed e-con e-parent\" data-id=\"3731f06\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-36bd04b e-con-full e-flex e-con e-child\" data-id=\"36bd04b\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-de9e31b elementor-widget elementor-widget-text-editor\" data-id=\"de9e31b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">Los <\/span><b>p\u00e9ptidos terap\u00e9uticos<\/b><span style=\"font-weight: 400;\"> representan uno de los segmentos de mayor crecimiento de la cartera biofarmac\u00e9utica. Abarcando nuevas entidades qu\u00edmicas pept\u00eddicas innovadoras, equivalentes gen\u00e9ricos de f\u00e1rmacos pept\u00eddicos establecidos, p\u00e9ptidos c\u00edclicos y modificados con perfiles de estabilidad mejorados, y mol\u00e9culas h\u00edbridas, esta clase diversa requiere enfoques anal\u00edticos que establezcan un puente entre la qu\u00edmica farmac\u00e9utica de mol\u00e9cula peque\u00f1a y la medicina biol\u00f3gica.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">La <\/span><b>caracterizaci\u00f3n<\/b><span style=\"font-weight: 400;\"> anal\u00edtica de los <\/span><b>p\u00e9ptidos terap\u00e9uticos<\/b><span style=\"font-weight: 400;\"> exige m\u00e9todos validados capaces de confirmar la integridad de la secuencia, evaluar la pureza frente a <\/span><b>impurezas<\/b><span style=\"font-weight: 400;\"> sint\u00e9ticas y <\/span><b>productos de degradaci\u00f3n<\/b><span style=\"font-weight: 400;\">, caracterizar las propiedades fisicoqu\u00edmicas y detectar modificaciones post-sint\u00e9ticas relevantes para la calidad.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">AMSbiopharma proporciona servicios anal\u00edticos integrales para <\/span><b>p\u00e9ptidos terap\u00e9uticos<\/b><span style=\"font-weight: 400;\"> y terap\u00e9uticos basados en amino\u00e1cidos en todas las fases de desarrollo, desde la <\/span><b>caracterizaci\u00f3n<\/b><span style=\"font-weight: 400;\"> temprana hasta los paquetes anal\u00edticos <\/span><b>CMC<\/b><span style=\"font-weight: 400;\"> completos para presentaci\u00f3n regulatoria.<\/span><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-07530db e-con-full e-flex e-con e-child\" data-id=\"07530db\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3337149 elementor-widget elementor-widget-image\" data-id=\"3337149\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"901\" height=\"545\" src=\"https:\/\/amsbiopharma.com\/wp-content\/uploads\/apb.png\" class=\"attachment-large size-large wp-image-3646\" alt=\"\" srcset=\"https:\/\/amsbiopharma.com\/wp-content\/uploads\/apb.png 901w, https:\/\/amsbiopharma.com\/wp-content\/uploads\/apb-300x181.png 300w, https:\/\/amsbiopharma.com\/wp-content\/uploads\/apb-768x465.png 768w\" sizes=\"(max-width: 901px) 100vw, 901px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-389bfd00 e-con-full e-flex e-con e-parent\" data-id=\"389bfd00\" data-element_type=\"container\" data-e-type=\"container\" id=\"discover-menu-container\">\n\t\t<div class=\"elementor-element elementor-element-4a961225 e-con-full title-container e-flex e-con 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\/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0e6ba00 elementor-widget elementor-widget-n-accordion\" data-id=\"0e6ba00\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;default_state&quot;:&quot;expanded&quot;,&quot;max_items_expended&quot;:&quot;one&quot;,&quot;n_accordion_animation_duration&quot;:{&quot;unit&quot;:&quot;ms&quot;,&quot;size&quot;:400,&quot;sizes&quot;:[]}}\" data-widget_type=\"nested-accordion.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"e-n-accordion\" aria-label=\"Accordion. Open links with Enter or Space, close with Escape, and navigate with Arrow Keys\">\n\t\t\t\t\t\t<details id=\"e-n-accordion-item-1510\" class=\"e-n-accordion-item\" open>\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"1\" tabindex=\"0\" aria-expanded=\"true\" aria-controls=\"e-n-accordion-item-1510\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><h3 class=\"e-n-accordion-item-title-text\"> An\u00e1lisis y Caracterizaci\u00f3n de P\u00e9ptidos Terap\u00e9uticos (Innovadores, Gen\u00e9ricos e H\u00edbridos) <\/h3><\/span>\n\t\t\t\t\t\t\t<span class='e-n-accordion-item-title-icon'>\n\t\t\t<span class='e-opened' ><svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-arrow-alt-circle-down\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M504 256c0 137-111 248-248 248S8 393 8 256 119 8 256 8s248 111 248 248zM212 140v116h-70.9c-10.7 0-16.1 13-8.5 20.5l114.9 114.3c4.7 4.7 12.2 4.7 16.9 0l114.9-114.3c7.6-7.6 2.2-20.5-8.5-20.5H300V140c0-6.6-5.4-12-12-12h-64c-6.6 0-12 5.4-12 12z\"><\/path><\/svg><\/span>\n\t\t\t<span class='e-closed'><svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-arrow-alt-circle-right\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 8c137 0 248 111 248 248S393 504 256 504 8 393 8 256 119 8 256 8zM140 300h116v70.9c0 10.7 13 16.1 20.5 8.5l114.3-114.9c4.7-4.7 4.7-12.2 0-16.9l-114.3-115c-7.6-7.6-20.5-2.2-20.5 8.5V212H140c-6.6 0-12 5.4-12 12v64c0 6.6 5.4 12 12 12z\"><\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-1510\" class=\"elementor-element elementor-element-73aa28e e-con-full e-flex e-con e-child\" data-id=\"73aa28e\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-1510\" class=\"elementor-element elementor-element-2ec210d e-flex e-con-boxed e-con e-child\" data-id=\"2ec210d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-41bcf12 elementor-widget elementor-widget-text-editor\" data-id=\"41bcf12\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">La <\/span><b>caracterizaci\u00f3n<\/b><span style=\"font-weight: 400;\"> anal\u00edtica integral de los <\/span><b>p\u00e9ptidos terap\u00e9uticos<\/b><span style=\"font-weight: 400;\"> requiere un enfoque multi-m\u00e9todo cubriendo la estructura primaria, la integridad de la secuencia, la pureza, las sustancias relacionadas y las propiedades fisicoqu\u00edmicas. Para los productos pept\u00eddicos gen\u00e9ricos, el programa debe abordar adicionalmente la <\/span><b>comparabilidad<\/b><span style=\"font-weight: 400;\"> anal\u00edtica con el medicamento de referencia.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">AMSbiopharma proporciona servicios de <\/span><b>caracterizaci\u00f3n<\/b><span style=\"font-weight: 400;\"> para <\/span><b>p\u00e9ptidos terap\u00e9uticos<\/b><span style=\"font-weight: 400;\">. La estructura primaria y la integridad de la secuencia se confirman por m\u00e9todos espectrom\u00e9tricos de masas, con la medida de masa intacta de alta resoluci\u00f3n y el <\/span><b>mapeo pept\u00eddico<\/b><span style=\"font-weight: 400;\"> proporcionando cobertura integral.<\/span><\/p>\n<p><b>Capacidades anal\u00edticas clave:<\/b><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Confirmaci\u00f3n de secuencia e integridad por masa intacta y <\/span><b>mapeo pept\u00eddico<\/b><\/li>\n<p> \t<\/p>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Perfilado de pureza y <\/span><b>sustancias relacionadas<\/b><span style=\"font-weight: 400;\"> por m\u00e9todos <\/span><b>HPLC<\/b><span style=\"font-weight: 400;\">.<\/span><\/li>\n<p> \t<\/p>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Caracterizaci\u00f3n<\/b><span style=\"font-weight: 400;\"> estructural de p\u00e9ptidos c\u00edclicos, modificados y conjugados<\/span><\/li>\n<p> \t<\/p>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Aplicable en p\u00e9ptidos lineales, c\u00edclicos, con puentes disulfuro y con modificaciones en el esqueleto<\/span><\/li>\n<p><\/ul>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t<details id=\"e-n-accordion-item-1511\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"2\" tabindex=\"-1\" aria-expanded=\"false\" aria-controls=\"e-n-accordion-item-1511\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><h3 class=\"e-n-accordion-item-title-text\"> An\u00e1lisis de Amino\u00e1cidos y Compuestos Relacionados \/ NON GLP <\/h3><\/span>\n\t\t\t\t\t\t\t<span class='e-n-accordion-item-title-icon'>\n\t\t\t<span class='e-opened' ><svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-arrow-alt-circle-down\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M504 256c0 137-111 248-248 248S8 393 8 256 119 8 256 8s248 111 248 248zM212 140v116h-70.9c-10.7 0-16.1 13-8.5 20.5l114.9 114.3c4.7 4.7 12.2 4.7 16.9 0l114.9-114.3c7.6-7.6 2.2-20.5-8.5-20.5H300V140c0-6.6-5.4-12-12-12h-64c-6.6 0-12 5.4-12 12z\"><\/path><\/svg><\/span>\n\t\t\t<span class='e-closed'><svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-arrow-alt-circle-right\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 8c137 0 248 111 248 248S393 504 256 504 8 393 8 256 119 8 256 8zM140 300h116v70.9c0 10.7 13 16.1 20.5 8.5l114.3-114.9c4.7-4.7 4.7-12.2 0-16.9l-114.3-115c-7.6-7.6-20.5-2.2-20.5 8.5V212H140c-6.6 0-12 5.4-12 12v64c0 6.6 5.4 12 12 12z\"><\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-1511\" class=\"elementor-element elementor-element-e2805c0 e-con-full e-flex e-con e-child\" data-id=\"e2805c0\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-1511\" class=\"elementor-element elementor-element-4d5b9b0 e-flex e-con-boxed e-con e-child\" data-id=\"4d5b9b0\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-662c895 elementor-widget elementor-widget-text-editor\" data-id=\"662c895\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">El an\u00e1lisis de <\/span><b>amino\u00e1cidos<\/b><span style=\"font-weight: 400;\"> proporciona informaci\u00f3n composicional esencial para la confirmaci\u00f3n de identidad y el <\/span><b>control de calidad<\/b><span style=\"font-weight: 400;\"> de prote\u00ednas, p\u00e9ptidos y <\/span><b>productos farmac\u00e9uticos<\/b><span style=\"font-weight: 400;\"> basados en amino\u00e1cidos. La determinaci\u00f3n de la composici\u00f3n sirve como ensayo de identidad, como herramienta para estimar el contenido proteico y como ensayo de <\/span><b>control de calidad<\/b><span style=\"font-weight: 400;\"> cuantitativo en productos formulados.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">AMSbiopharma ofrece servicios anal\u00edticos validados para la cuantificaci\u00f3n de <\/span><b>amino\u00e1cidos<\/b><span style=\"font-weight: 400;\"> y compuestos relacionados en <\/span><b>sustancias activas<\/b><span style=\"font-weight: 400;\">, <\/span><b>productos farmac\u00e9uticos<\/b><span style=\"font-weight: 400;\"> y matrices biol\u00f3gicas, aplicando protocolos validados de hidr\u00f3lisis y derivatizaci\u00f3n seguidos de separaci\u00f3n cromatogr\u00e1fica y detecci\u00f3n.<\/span><\/p>\n<p><b>Capacidades anal\u00edticas clave:<\/b><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">An\u00e1lisis de composici\u00f3n de <\/span><b>amino\u00e1cidos<\/b><span style=\"font-weight: 400;\"> para confirmaci\u00f3n de identidad de prote\u00ednas y p\u00e9ptidos<\/span><\/li>\n<p> \t<\/p>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cuantificaci\u00f3n de todos los <\/span><b>amino\u00e1cidos<\/b><span style=\"font-weight: 400;\"> proteog\u00e9nicos<\/span><\/li>\n<p> \t<\/p>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Aplicable para la <\/span><b>caracterizaci\u00f3n<\/b><span style=\"font-weight: 400;\"> de <\/span><b>sustancias activas<\/b><span style=\"font-weight: 400;\"> y el <\/span><b>control de calidad<\/b><\/li>\n<p> \t<\/p>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Soporte para la estimaci\u00f3n del contenido proteico por an\u00e1lisis de <\/span><b>amino\u00e1cidos<\/b><\/li>\n<p> \t<\/p>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Aplicable en <\/span><b>sustancias activas<\/b><span style=\"font-weight: 400;\">, <\/span><b>productos farmac\u00e9uticos<\/b><span style=\"font-weight: 400;\"> y matrices biol\u00f3gicas<\/span><\/li>\n<p> \t<\/p>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Documentaci\u00f3n completa de validaci\u00f3n para presentaciones regulatorias<\/span><\/li>\n<p><\/ul>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t<details id=\"e-n-accordion-item-1512\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"3\" tabindex=\"-1\" aria-expanded=\"false\" aria-controls=\"e-n-accordion-item-1512\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><h3 class=\"e-n-accordion-item-title-text\"> Mapeo Pept\u00eddico \/ NON GLP <\/h3><\/span>\n\t\t\t\t\t\t\t<span class='e-n-accordion-item-title-icon'>\n\t\t\t<span class='e-opened' ><svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-arrow-alt-circle-down\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M504 256c0 137-111 248-248 248S8 393 8 256 119 8 256 8s248 111 248 248zM212 140v116h-70.9c-10.7 0-16.1 13-8.5 20.5l114.9 114.3c4.7 4.7 12.2 4.7 16.9 0l114.9-114.3c7.6-7.6 2.2-20.5-8.5-20.5H300V140c0-6.6-5.4-12-12-12h-64c-6.6 0-12 5.4-12 12z\"><\/path><\/svg><\/span>\n\t\t\t<span class='e-closed'><svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-arrow-alt-circle-right\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 8c137 0 248 111 248 248S393 504 256 504 8 393 8 256 119 8 256 8zM140 300h116v70.9c0 10.7 13 16.1 20.5 8.5l114.3-114.9c4.7-4.7 4.7-12.2 0-16.9l-114.3-115c-7.6-7.6-20.5-2.2-20.5 8.5V212H140c-6.6 0-12 5.4-12 12v64c0 6.6 5.4 12 12 12z\"><\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-1512\" class=\"elementor-element elementor-element-079fb3b e-con-full e-flex e-con e-child\" data-id=\"079fb3b\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-1512\" class=\"elementor-element elementor-element-6ab8ab0 e-flex e-con-boxed e-con e-child\" data-id=\"6ab8ab0\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c11ac57 elementor-widget elementor-widget-text-editor\" data-id=\"c11ac57\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">El <\/span><b>mapeo pept\u00eddico<\/b><span style=\"font-weight: 400;\"> es una de las t\u00e9cnicas de <\/span><b>caracterizaci\u00f3n<\/b><span style=\"font-weight: 400;\"> anal\u00edtica m\u00e1s potentes e informativas para los terap\u00e9uticos proteicos y pept\u00eddicos. Al digerir enzim\u00e1ticamente la prote\u00edna en fragmentos pept\u00eddicos definidos y analizar la mezcla resultante por <\/span><b>LC-MS\/MS<\/b><span style=\"font-weight: 400;\">, el <\/span><b>mapeo pept\u00eddico<\/b><span style=\"font-weight: 400;\"> proporciona cobertura integral de la secuencia, confirma la integridad de la estructura primaria y detecta modificaciones post-traduccionales y degradaci\u00f3n qu\u00edmica a nivel molecular.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">AMSbiopharma proporciona servicios de <\/span><b>mapeo pept\u00eddico<\/b><span style=\"font-weight: 400;\"> validados usando protocolos de digesti\u00f3n optimizados y an\u00e1lisis por <\/span><b>LC-MS\/MS<\/b><span style=\"font-weight: 400;\">, con alta cobertura de secuencia e identificaci\u00f3n y localizaci\u00f3n con confianza de modificaciones post-traduccionales incluyendo <\/span><b>glicosilaci\u00f3n<\/b><span style=\"font-weight: 400;\">, oxidaci\u00f3n, deamidaci\u00f3n, fosforilaci\u00f3n y asignaci\u00f3n de puentes disulfuro.<\/span><\/p>\n<p><b>Capacidades anal\u00edticas clave:<\/b><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Mapeo pept\u00eddico<\/b><span style=\"font-weight: 400;\"> basado en <\/span><b>LC-MS\/MS<\/b><span style=\"font-weight: 400;\"> con alta cobertura de secuencia<\/span><\/li>\n<p> \t<\/p>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Identificaci\u00f3n y localizaci\u00f3n de modificaciones post-traduccionales<\/span><\/li>\n<p> \t<\/p>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Mapeo de sitios de <\/span><b>glicosilaci\u00f3n<\/b><span style=\"font-weight: 400;\"> y <\/span><b>caracterizaci\u00f3n<\/b><span style=\"font-weight: 400;\"> de glucop\u00e9ptidos<\/span><\/li>\n<p> \t<\/p>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Mapeo de puentes disulfuro y determinaci\u00f3n de ciste\u00edna libre<\/span><\/li>\n<p> \t<\/p>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Monitorizaci\u00f3n de deamidaci\u00f3n, oxidaci\u00f3n y otras degradaciones qu\u00edmicas<\/span><\/li>\n<p><\/ul>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t<details id=\"e-n-accordion-item-1513\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"4\" tabindex=\"-1\" aria-expanded=\"false\" aria-controls=\"e-n-accordion-item-1513\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><h3 class=\"e-n-accordion-item-title-text\"> Detecci\u00f3n y Cuantificaci\u00f3n de P\u00e9ptidos Sint\u00e9ticos (LC-MS\/MS) <\/h3><\/span>\n\t\t\t\t\t\t\t<span class='e-n-accordion-item-title-icon'>\n\t\t\t<span class='e-opened' ><svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-arrow-alt-circle-down\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M504 256c0 137-111 248-248 248S8 393 8 256 119 8 256 8s248 111 248 248zM212 140v116h-70.9c-10.7 0-16.1 13-8.5 20.5l114.9 114.3c4.7 4.7 12.2 4.7 16.9 0l114.9-114.3c7.6-7.6 2.2-20.5-8.5-20.5H300V140c0-6.6-5.4-12-12-12h-64c-6.6 0-12 5.4-12 12z\"><\/path><\/svg><\/span>\n\t\t\t<span class='e-closed'><svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-arrow-alt-circle-right\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 8c137 0 248 111 248 248S393 504 256 504 8 393 8 256 119 8 256 8zM140 300h116v70.9c0 10.7 13 16.1 20.5 8.5l114.3-114.9c4.7-4.7 4.7-12.2 0-16.9l-114.3-115c-7.6-7.6-20.5-2.2-20.5 8.5V212H140c-6.6 0-12 5.4-12 12v64c0 6.6 5.4 12 12 12z\"><\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-1513\" class=\"elementor-element elementor-element-6f4164c e-con-full e-flex e-con e-child\" data-id=\"6f4164c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-1513\" class=\"elementor-element elementor-element-bff0e92 e-flex e-con-boxed e-con e-child\" data-id=\"bff0e92\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ea12887 elementor-widget elementor-widget-text-editor\" data-id=\"ea12887\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">La cuantificaci\u00f3n precisa y sensible de <\/span><b>p\u00e9ptidos terap\u00e9uticos<\/b><span style=\"font-weight: 400;\"> sint\u00e9ticos en matrices biol\u00f3gicas complejas es un requisito <\/span><b>bioanal\u00edtico<\/b><span style=\"font-weight: 400;\"> especializado para estudios PK\/PD y programas de farmacolog\u00eda cl\u00ednica. La similitud estructural de los f\u00e1rmacos pept\u00eddicos con las especies pept\u00eddicas end\u00f3genas, combinada con su susceptibilidad a la degradaci\u00f3n enzim\u00e1tica, requiere un desarrollo de m\u00e9todos cuidadoso para garantizar la sensibilidad, selectividad y estabilidad.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">AMSbiopharma proporciona servicios <\/span><b>bioanal\u00edticos<\/b><span style=\"font-weight: 400;\"> por <\/span><b>LC-MS\/MS<\/b><span style=\"font-weight: 400;\"> para la detecci\u00f3n y cuantificaci\u00f3n de <\/span><b>p\u00e9ptidos terap\u00e9uticos<\/b><span style=\"font-weight: 400;\"> sint\u00e9ticos en plasma, suero, orina y otras matrices biol\u00f3gicas, con validaci\u00f3n completa conforme al <\/span><b>ICH M10<\/b><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><b>Capacidades anal\u00edticas clave:<\/b><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">M\u00e9todos <\/span><b>LC-MS\/MS<\/b><span style=\"font-weight: 400;\"> para cuantificaci\u00f3n de p\u00e9ptidos sint\u00e9ticos en matrices biol\u00f3gicas<\/span><\/li>\n<p> \t<\/p>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Desarrollo de m\u00e9todos que aborda <\/span><b>estabilidad<\/b><span style=\"font-weight: 400;\"> del p\u00e9ptido, extracci\u00f3n y sensibilidad<\/span><\/li>\n<p> \t<\/p>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Aplicable en plasma, suero, orina y otras matrices biol\u00f3gicas<\/span><\/li>\n<p><\/ul>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<div class=\"entry-summary\">\nAn\u00e1lisis de P\u00e9ptidos y Amino\u00e1cidos Servicios anal\u00edticos validados para p\u00e9ptidos terap\u00e9uticos, amino\u00e1cidos y terap\u00e9uticos sint\u00e9ticos basados en p\u00e9ptidos en todas las fases de desarrollo. Los p\u00e9ptidos terap\u00e9uticos representan uno de los segmentos de mayor crecimiento de la cartera biofarmac\u00e9utica. Abarcando&hellip;\n<\/div>\n<div class=\"link-more\"><a href=\"https:\/\/amsbiopharma.com\/es\/analisis-de-biofarmaceuticos-basados-en-proteinas\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &ldquo;An\u00e1lisis de P\u00e9ptidos y Amino\u00e1cidos\/ NO GLP&rdquo;<\/span>&hellip;<\/a><\/div>\n","protected":false},"author":1,"featured_media":4763,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"class_list":["post-3842","page","type-page","status-publish","has-post-thumbnail","hentry","entry"],"_links":{"self":[{"href":"https:\/\/amsbiopharma.com\/es\/wp-json\/wp\/v2\/pages\/3842","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/amsbiopharma.com\/es\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/amsbiopharma.com\/es\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/amsbiopharma.com\/es\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/amsbiopharma.com\/es\/wp-json\/wp\/v2\/comments?post=3842"}],"version-history":[{"count":34,"href":"https:\/\/amsbiopharma.com\/es\/wp-json\/wp\/v2\/pages\/3842\/revisions"}],"predecessor-version":[{"id":6915,"href":"https:\/\/amsbiopharma.com\/es\/wp-json\/wp\/v2\/pages\/3842\/revisions\/6915"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/amsbiopharma.com\/es\/wp-json\/wp\/v2\/media\/4763"}],"wp:attachment":[{"href":"https:\/\/amsbiopharma.com\/es\/wp-json\/wp\/v2\/media?parent=3842"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}