{"id":6517,"date":"2026-09-14T10:59:04","date_gmt":"2026-09-14T08:59:04","guid":{"rendered":"https:\/\/amsbiopharma.com\/analisis-de-proteinas\/"},"modified":"2026-09-23T15:08:51","modified_gmt":"2026-09-23T13:08:51","slug":"analisis-de-proteinas","status":"publish","type":"page","link":"https:\/\/amsbiopharma.com\/es\/analisis-de-proteinas\/","title":{"rendered":"An\u00e1lisis de Prote\u00ednas"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"6517\" class=\"elementor elementor-6517 elementor-6512\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1a2acea8 e-flex e-con-boxed e-con e-parent\" data-id=\"1a2acea8\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-292da77a e-con-full e-flex e-con e-child\" data-id=\"292da77a\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-1c9a1f9d e-con-full e-flex e-con e-child\" data-id=\"1c9a1f9d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a6483c1 elementor-widget elementor-widget-heading\" data-id=\"a6483c1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">An\u00e1lisis de Prote\u00ednas<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-61d112e5 e-con-full e-flex e-con e-child\" data-id=\"61d112e5\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;video&quot;,&quot;background_video_link&quot;:&quot;https:\\\/\\\/amsbiopharma.com\\\/wp-content\\\/uploads\\\/Clip10_Bioanalysis_Biomarkers.mp4&quot;,&quot;background_video_end&quot;:30}\">\n\t\t<div class=\"elementor-background-video-container elementor-hidden-mobile\">\n\t\t\t\t\t\t\t<video class=\"elementor-background-video-hosted\" role=\"presentation\" autoplay muted playsinline loop><\/video>\n\t\t\t\t\t<\/div><div class=\"elementor-element elementor-element-e7e54a3 e-con-full e-flex e-con e-child\" data-id=\"e7e54a3\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;video&quot;,&quot;background_video_link&quot;:&quot;https:\\\/\\\/amsbiopharma.com\\\/wp-content\\\/uploads\\\/Clip10_Bioanalysis_Biomarkers2.mp4&quot;,&quot;background_play_on_mobile&quot;:&quot;yes&quot;,&quot;background_play_once&quot;:&quot;yes&quot;,&quot;background_video_end&quot;:13,&quot;background_video_start&quot;:0}\">\n\t\t<div class=\"elementor-background-video-container\">\n\t\t\t\t\t\t\t<video class=\"elementor-background-video-hosted\" role=\"presentation\" autoplay muted playsinline><\/video>\n\t\t\t\t\t<\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8e2d49b e-flex e-con-boxed e-con e-parent\" data-id=\"8e2d49b\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-2ce3633 e-con-full e-flex e-con e-child\" data-id=\"2ce3633\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1cf95f4 elementor-widget elementor-widget-heading\" data-id=\"1cf95f4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Servicios avanzados de an\u00e1lisis de prote\u00ednas basados en espectrometr\u00eda de masas para la caracterizaci\u00f3n, cuantificaci\u00f3n y evaluaci\u00f3n estructural.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d6afdf6 elementor-widget elementor-widget-text-editor\" data-id=\"d6afdf6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">El an\u00e1lisis avanzado de prote\u00ednas a nivel molecular \u2014peso molecular intacto, caracterizaci\u00f3n de isoformas, perfilado de <\/span><b>glicosilaci\u00f3n<\/b><span style=\"font-weight: 400;\">, compromiso f\u00e1rmaco-prote\u00edna y cuantificaci\u00f3n espec\u00edfica de prote\u00ednas\u2014 proporciona la comprensi\u00f3n mecan\u00edstica y los datos de <\/span><b>atributos de calidad<\/b><span style=\"font-weight: 400;\"> esenciales para el desarrollo y el <\/span><b>control de calidad<\/b><span style=\"font-weight: 400;\"> de los terap\u00e9uticos biol\u00f3gicos. La espectrometr\u00eda de masas de alta resoluci\u00f3n ha transformado la profundidad y precisi\u00f3n de la informaci\u00f3n disponible.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">AMSbiopharma proporciona una cartera enfocada de servicios avanzados de an\u00e1lisis de prote\u00ednas, aplicando espectrometr\u00eda de masas de alta resoluci\u00f3n y t\u00e9cnicas ortogonales complementarias para proporcionar <\/span><b>caracterizaci\u00f3n<\/b><span style=\"font-weight: 400;\"> molecular detallada de prote\u00ednas terap\u00e9uticas, anticuerpos y otras entidades biol\u00f3gicas.<\/span><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a2cd724 e-con-full e-flex e-con e-child\" data-id=\"a2cd724\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3604d60 elementor-widget elementor-widget-image\" data-id=\"3604d60\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"900\" height=\"771\" src=\"https:\/\/amsbiopharma.com\/wp-content\/uploads\/img.png\" class=\"attachment-large size-large wp-image-3616\" alt=\"\" srcset=\"https:\/\/amsbiopharma.com\/wp-content\/uploads\/img.png 900w, https:\/\/amsbiopharma.com\/wp-content\/uploads\/img-300x257.png 300w, https:\/\/amsbiopharma.com\/wp-content\/uploads\/img-768x658.png 768w\" sizes=\"(max-width: 900px) 100vw, 900px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-569a767 e-con-full e-flex e-con e-parent\" data-id=\"569a767\" data-element_type=\"container\" data-e-type=\"container\" id=\"discover-menu-container\">\n\t\t<div class=\"elementor-element elementor-element-60d507a e-con-full title-container e-flex e-con e-child\" data-id=\"60d507a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ad48d71 elementor-widget elementor-widget-heading\" data-id=\"ad48d71\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Descubre<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-461c7f6 elementor-widget elementor-widget-html\" data-id=\"461c7f6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-plus-circle\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 8C119 8 8 119 8 256s111 248 248 248 248-111 248-248S393 8 256 8zm144 276c0 6.6-5.4 12-12 12h-92v92c0 6.6-5.4 12-12 12h-56c-6.6 0-12-5.4-12-12v-92h-92c-6.6 0-12-5.4-12-12v-56c0-6.6 5.4-12 12-12h92v-92c0-6.6 5.4-12 12-12h56c6.6 0 12 5.4 12 12v92h92c6.6 0 12 5.4 12 12v56z\"><\/path><\/svg>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-277ed7c elementor-nav-menu--dropdown-none discover-menu elementor-widget elementor-widget-nav-menu\" data-id=\"277ed7c\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;layout&quot;:&quot;vertical&quot;,&quot;submenu_icon&quot;:{&quot;value&quot;:&quot;&lt;svg aria-hidden=\\&quot;true\\&quot; 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Open links with Enter or Space, close with Escape, and navigate with Arrow Keys\">\n\t\t\t\t\t\t<details id=\"e-n-accordion-item-2160\" class=\"e-n-accordion-item\" open>\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"1\" tabindex=\"0\" aria-expanded=\"true\" aria-controls=\"e-n-accordion-item-2160\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><h3 class=\"e-n-accordion-item-title-text\"> An\u00e1lisis de Peso Molecular Intacto e Isoformas de Prote\u00ednas \/ Non-GMP \/ NON GLP <\/h3><\/span>\n\t\t\t\t\t\t\t<span class='e-n-accordion-item-title-icon'>\n\t\t\t<span class='e-opened' ><svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-arrow-alt-circle-down\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M504 256c0 137-111 248-248 248S8 393 8 256 119 8 256 8s248 111 248 248zM212 140v116h-70.9c-10.7 0-16.1 13-8.5 20.5l114.9 114.3c4.7 4.7 12.2 4.7 16.9 0l114.9-114.3c7.6-7.6 2.2-20.5-8.5-20.5H300V140c0-6.6-5.4-12-12-12h-64c-6.6 0-12 5.4-12 12z\"><\/path><\/svg><\/span>\n\t\t\t<span class='e-closed'><svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-arrow-alt-circle-right\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 8c137 0 248 111 248 248S393 504 256 504 8 393 8 256 119 8 256 8zM140 300h116v70.9c0 10.7 13 16.1 20.5 8.5l114.3-114.9c4.7-4.7 4.7-12.2 0-16.9l-114.3-115c-7.6-7.6-20.5-2.2-20.5 8.5V212H140c-6.6 0-12 5.4-12 12v64c0 6.6 5.4 12 12 12z\"><\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-2160\" class=\"elementor-element elementor-element-7fc7840 e-con-full e-flex e-con e-child\" data-id=\"7fc7840\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-2160\" class=\"elementor-element elementor-element-81f4f7a e-flex e-con-boxed e-con e-child\" data-id=\"81f4f7a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-070160e elementor-widget elementor-widget-text-editor\" data-id=\"070160e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">La determinaci\u00f3n precisa del <\/span><b>peso molecular<\/b><span style=\"font-weight: 400;\"> de un terap\u00e9utico proteico intacto o reducido por espectrometr\u00eda de masas proporciona datos de identidad fundamentales, confirmando la integridad de la secuencia primaria y la presencia de cualquier modificaci\u00f3n que altere la masa molecular.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">AMSbiopharma aplica espectrometr\u00eda de masas de alta resoluci\u00f3n para el an\u00e1lisis de prote\u00ednas intactas y middle-up, con etapas de desalinizaci\u00f3n o desglicosilaci\u00f3n en l\u00ednea aplicadas seg\u00fan corresponda. El software de deconvoluci\u00f3n del estado de carga proporciona masas medias y monoisot\u00f3picas precisas para las especies proteicas, con las distribuciones de isoformas cuantificadas por abundancia relativa de se\u00f1al.<\/span><\/p>\n<p><b>Capacidades anal\u00edticas clave:<\/b><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Determinaci\u00f3n del <\/span><b>peso molecular<\/b><span style=\"font-weight: 400;\"> de la prote\u00edna intacta por espectrometr\u00eda de masas de alta resoluci\u00f3n<\/span><\/li>\n<p> \t<\/p>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">An\u00e1lisis middle-up de fragmentos de anticuerpos (Fc, Fab, scFv)<\/span><\/li>\n<p> \t<\/p>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Mapeo de la distribuci\u00f3n de glicoformas por espectrometr\u00eda de masas intacta<\/span><\/li>\n<p> \t<\/p>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Deconvoluci\u00f3n del estado de carga para la determinaci\u00f3n precisa de la masa<\/span><\/li>\n<p> \t<\/p>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Aplicable en <\/span><b>mAbs<\/b><span style=\"font-weight: 400;\">, fusiones Fc, <\/span><b>ADC<\/b><span style=\"font-weight: 400;\">, biespec\u00edficos y otros biol\u00f3gicos<\/span><\/li>\n<p><\/ul>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t<details id=\"e-n-accordion-item-2161\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"2\" tabindex=\"-1\" aria-expanded=\"false\" aria-controls=\"e-n-accordion-item-2161\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><h3 class=\"e-n-accordion-item-title-text\"> An\u00e1lisis de Glucop\u00e9ptidos y Glicanos Liberados \/ NON GLP <\/h3><\/span>\n\t\t\t\t\t\t\t<span class='e-n-accordion-item-title-icon'>\n\t\t\t<span class='e-opened' ><svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-arrow-alt-circle-down\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M504 256c0 137-111 248-248 248S8 393 8 256 119 8 256 8s248 111 248 248zM212 140v116h-70.9c-10.7 0-16.1 13-8.5 20.5l114.9 114.3c4.7 4.7 12.2 4.7 16.9 0l114.9-114.3c7.6-7.6 2.2-20.5-8.5-20.5H300V140c0-6.6-5.4-12-12-12h-64c-6.6 0-12 5.4-12 12z\"><\/path><\/svg><\/span>\n\t\t\t<span class='e-closed'><svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-arrow-alt-circle-right\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 8c137 0 248 111 248 248S393 504 256 504 8 393 8 256 119 8 256 8zM140 300h116v70.9c0 10.7 13 16.1 20.5 8.5l114.3-114.9c4.7-4.7 4.7-12.2 0-16.9l-114.3-115c-7.6-7.6-20.5-2.2-20.5 8.5V212H140c-6.6 0-12 5.4-12 12v64c0 6.6 5.4 12 12 12z\"><\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-2161\" class=\"elementor-element elementor-element-cf6448a e-con-full e-flex e-con e-child\" data-id=\"cf6448a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-2161\" class=\"elementor-element elementor-element-74521bc e-flex e-con-boxed e-con e-child\" data-id=\"74521bc\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f42cf68 elementor-widget elementor-widget-text-editor\" data-id=\"f42cf68\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">La <\/span><b>glicosilaci\u00f3n<\/b><span style=\"font-weight: 400;\"> es uno de los <\/span><b>atributos de calidad<\/b><span style=\"font-weight: 400;\"> m\u00e1s cr\u00edticos de los terap\u00e9uticos biol\u00f3gicos, con influencia directa en la farmacocin\u00e9tica, la funci\u00f3n efectora, la <\/span><b>inmunogenicidad<\/b><span style=\"font-weight: 400;\"> y la eficacia cl\u00ednica. El perfil de <\/span><b>glicosilaci\u00f3n<\/b><span style=\"font-weight: 400;\"> debe caracterizarse completamente para la presentaci\u00f3n regulatoria y monitorizarse como parte del <\/span><b>control de calidad<\/b><span style=\"font-weight: 400;\"> rutinario.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">AMSbiopharma proporciona servicios integrales de <\/span><b>caracterizaci\u00f3n<\/b><span style=\"font-weight: 400;\"> de glicanos tanto a nivel de glic\u00e1n liberado como de glucop\u00e9ptido. El an\u00e1lisis de N-glicanos liberados por <\/span><b>HPLC<\/b> <span style=\"font-weight: 400;\">con detecci\u00f3n de fluorescencia<\/span><span style=\"font-weight: 400;\"> o <\/span><b>LC-MS\/MS<\/b><span style=\"font-weight: 400;\"> proporciona datos cuantitativos de composici\u00f3n de glicanos. El an\u00e1lisis de glucop\u00e9ptidos por <\/span><b>LC-MS\/MS<\/b><span style=\"font-weight: 400;\"> proporciona informaci\u00f3n de <\/span><b>glicosilaci\u00f3n<\/b><span style=\"font-weight: 400;\"> espec\u00edfica de sitio.<\/span><\/p>\n<p><b>Capacidades anal\u00edticas clave:<\/b><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Perfilado de N-glicanos liberados por <\/span><b>HPLC<\/b><span style=\"font-weight: 400;\"> con detecci\u00f3n de fluorescencia<\/span><\/li>\n<p> \t<\/p>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Identificaci\u00f3n y cuantificaci\u00f3n relativa de glicanos por <\/span><b>LC-MS\/MS<\/b><\/li>\n<p> \t<\/p>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">An\u00e1lisis de <\/span><b>glicosilaci\u00f3n<\/b><span style=\"font-weight: 400;\"> espec\u00edfica de sitio por mapeo de glucop\u00e9ptidos<\/span><\/li>\n<p> \t<\/p>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Caracterizaci\u00f3n<\/b><span style=\"font-weight: 400;\"> de O-glicosilaci\u00f3n para clases biol\u00f3gicas relevantes<\/span><\/li>\n<p> \t<\/p>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Aplicable en <\/span><b>mAbs<\/b><span style=\"font-weight: 400;\">, prote\u00ednas de fusi\u00f3n Fc, enzimas terap\u00e9uticas y <\/span><b>biosimilares<\/b><\/li>\n<p> \t<\/p>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">M\u00e9todos validados para presentaciones <\/span><b>CMC<\/b><span style=\"font-weight: 400;\"> y <\/span><b>control de calidad<\/b><span style=\"font-weight: 400;\"> rutinario<\/span><\/li>\n<p><\/ul>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t<details id=\"e-n-accordion-item-2162\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"3\" tabindex=\"-1\" aria-expanded=\"false\" aria-controls=\"e-n-accordion-item-2162\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><h3 class=\"e-n-accordion-item-title-text\"> An\u00e1lisis del Compromiso F\u00e1rmaco-Prote\u00edna \/ NON GLP <\/h3><\/span>\n\t\t\t\t\t\t\t<span class='e-n-accordion-item-title-icon'>\n\t\t\t<span class='e-opened' ><svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-arrow-alt-circle-down\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M504 256c0 137-111 248-248 248S8 393 8 256 119 8 256 8s248 111 248 248zM212 140v116h-70.9c-10.7 0-16.1 13-8.5 20.5l114.9 114.3c4.7 4.7 12.2 4.7 16.9 0l114.9-114.3c7.6-7.6 2.2-20.5-8.5-20.5H300V140c0-6.6-5.4-12-12-12h-64c-6.6 0-12 5.4-12 12z\"><\/path><\/svg><\/span>\n\t\t\t<span class='e-closed'><svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-arrow-alt-circle-right\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 8c137 0 248 111 248 248S393 504 256 504 8 393 8 256 119 8 256 8zM140 300h116v70.9c0 10.7 13 16.1 20.5 8.5l114.3-114.9c4.7-4.7 4.7-12.2 0-16.9l-114.3-115c-7.6-7.6-20.5-2.2-20.5 8.5V212H140c-6.6 0-12 5.4-12 12v64c0 6.6 5.4 12 12 12z\"><\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-2162\" class=\"elementor-element elementor-element-458a35c e-con-full e-flex e-con e-child\" data-id=\"458a35c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-2162\" class=\"elementor-element elementor-element-a10bc94 e-flex e-con-boxed e-con e-child\" data-id=\"a10bc94\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3f21cce elementor-widget elementor-widget-text-editor\" data-id=\"3f21cce\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">La caracterizaci\u00f3n de la interacci\u00f3n entre una mol\u00e9cula terap\u00e9utica y su diana proteica proporciona informaci\u00f3n fundamental para la <\/span><b>caracterizaci\u00f3n<\/b><span style=\"font-weight: 400;\"> farmacol\u00f3gica y los estudios de mecanismo de acci\u00f3n. La evaluaci\u00f3n cuantitativa del compromiso de diana proporciona evidencia mecan\u00edstica de que el f\u00e1rmaco est\u00e1 alcanzando y uni\u00e9ndose a su diana prevista in vivo.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">AMSbiopharma proporciona servicios anal\u00edticos para la evaluaci\u00f3n del compromiso f\u00e1rmaco-prote\u00edna, aplicando enfoques basados en espectrometr\u00eda de masas para datos cuantitativos sobre la interacci\u00f3n f\u00e1rmaco-diana, apoyando la <\/span><b>caracterizaci\u00f3n<\/b><span style=\"font-weight: 400;\"> del mecanismo de acci\u00f3n y los estudios de relaci\u00f3n estructura-actividad.<\/span><\/p>\n<p><b>Capacidades anal\u00edticas clave:<\/b><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Enfoques basados en espectrometr\u00eda de masas para interacciones covalentes y no covalentes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Aplicable en diversas modalidades terap\u00e9uticas y clases de prote\u00ednas diana<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Soporte para estudios de <\/span><b>caracterizaci\u00f3n<\/b><span style=\"font-weight: 400;\"> del mecanismo de acci\u00f3n<\/span><\/li>\n<p> \t<\/p>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Soporte anal\u00edtico para datos de relaci\u00f3n estructura-actividad<\/span><\/li>\n<p> \t<\/p>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Integraci\u00f3n con el dise\u00f1o de programas de <\/span><b>biomarcadores<\/b><span style=\"font-weight: 400;\"> farmacodin\u00e1micos<\/span><\/li>\n<p><\/ul>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t<details id=\"e-n-accordion-item-2163\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"4\" tabindex=\"-1\" aria-expanded=\"false\" aria-controls=\"e-n-accordion-item-2163\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><h3 class=\"e-n-accordion-item-title-text\"> Cuantificaci\u00f3n Espec\u00edfica de Prote\u00ednas <\/h3><\/span>\n\t\t\t\t\t\t\t<span class='e-n-accordion-item-title-icon'>\n\t\t\t<span class='e-opened' ><svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-arrow-alt-circle-down\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M504 256c0 137-111 248-248 248S8 393 8 256 119 8 256 8s248 111 248 248zM212 140v116h-70.9c-10.7 0-16.1 13-8.5 20.5l114.9 114.3c4.7 4.7 12.2 4.7 16.9 0l114.9-114.3c7.6-7.6 2.2-20.5-8.5-20.5H300V140c0-6.6-5.4-12-12-12h-64c-6.6 0-12 5.4-12 12z\"><\/path><\/svg><\/span>\n\t\t\t<span class='e-closed'><svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-arrow-alt-circle-right\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 8c137 0 248 111 248 248S393 504 256 504 8 393 8 256 119 8 256 8zM140 300h116v70.9c0 10.7 13 16.1 20.5 8.5l114.3-114.9c4.7-4.7 4.7-12.2 0-16.9l-114.3-115c-7.6-7.6-20.5-2.2-20.5 8.5V212H140c-6.6 0-12 5.4-12 12v64c0 6.6 5.4 12 12 12z\"><\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-2163\" class=\"elementor-element elementor-element-15b85b9 e-con-full e-flex e-con e-child\" data-id=\"15b85b9\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-2163\" class=\"elementor-element elementor-element-1ec829d e-flex e-con-boxed e-con e-child\" data-id=\"1ec829d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f7a2d7a elementor-widget elementor-widget-text-editor\" data-id=\"f7a2d7a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">La cuantificaci\u00f3n precisa y selectiva de prote\u00ednas espec\u00edficas en matrices biol\u00f3gicas complejas es un requisito anal\u00edtico cr\u00edtico en aplicaciones <\/span><b>bioanal\u00edticas<\/b><span style=\"font-weight: 400;\">, farmacodin\u00e1micas y de <\/span><b>control de calidad<\/b><span style=\"font-weight: 400;\">. El m\u00e9todo de elecci\u00f3n depende del contexto: los enfoques de inmunoensayo ofrecen alta sensibilidad para dianas de baja abundancia en matrices complejas, mientras que los m\u00e9todos basados en espectrometr\u00eda de masas ofrecen mayor especificidad y capacidad de multiplexaci\u00f3n.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">AMSbiopharma proporciona servicios validados de cuantificaci\u00f3n espec\u00edfica de prote\u00ednas aplicando enfoques de ensayo de uni\u00f3n a ligando (<\/span><b>LBA<\/b><span style=\"font-weight: 400;\">) y basados en <\/span><b>LC-MS\/MS<\/b><span style=\"font-weight: 400;\">. Los est\u00e1ndares internos de p\u00e9ptidos marcados con is\u00f3topos estables garantizan una cuantificaci\u00f3n exacta y reproducible con correcci\u00f3n apropiada para los efectos de matriz.<\/span><\/p>\n<p><b>Capacidades anal\u00edticas clave:<\/b><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cuantificaci\u00f3n espec\u00edfica de prote\u00ednas por <\/span><b>LC-MS\/MS<\/b><span style=\"font-weight: 400;\"> validado con est\u00e1ndares de is\u00f3topos estables<\/span><\/li>\n<p> \t<\/p>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cuantificaci\u00f3n de prote\u00ednas por ensayo de uni\u00f3n a ligando (<\/span><b>LBA<\/b><span style=\"font-weight: 400;\">) para alta sensibilidad<\/span><\/li>\n<p> \t<\/p>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Aplicable en aplicaciones <\/span><b>bioanal\u00edticas<\/b><span style=\"font-weight: 400;\">, farmacodin\u00e1micas y de <\/span><b>control de calidad<\/b><\/li>\n<p> \t<\/p>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Capacidades de cuantificaci\u00f3n de prote\u00ednas<\/span><\/li>\n<p> \t<\/p>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Aplicable en plasma, suero, tejido y matrices farmac\u00e9uticas<\/span><\/li>\n<p><\/ul>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<div class=\"entry-summary\">\nAn\u00e1lisis de Prote\u00ednas Servicios avanzados de an\u00e1lisis de prote\u00ednas basados en espectrometr\u00eda de masas para la caracterizaci\u00f3n, cuantificaci\u00f3n y evaluaci\u00f3n estructural. El an\u00e1lisis avanzado de prote\u00ednas a nivel molecular \u2014peso molecular intacto, caracterizaci\u00f3n de isoformas, perfilado de glicosilaci\u00f3n, compromiso f\u00e1rmaco-prote\u00edna&hellip;\n<\/div>\n<div class=\"link-more\"><a href=\"https:\/\/amsbiopharma.com\/es\/analisis-de-proteinas\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &ldquo;An\u00e1lisis de Prote\u00ednas&rdquo;<\/span>&hellip;<\/a><\/div>\n","protected":false},"author":6,"featured_media":4763,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"class_list":["post-6517","page","type-page","status-publish","has-post-thumbnail","hentry","entry"],"_links":{"self":[{"href":"https:\/\/amsbiopharma.com\/es\/wp-json\/wp\/v2\/pages\/6517","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/amsbiopharma.com\/es\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/amsbiopharma.com\/es\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/amsbiopharma.com\/es\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/amsbiopharma.com\/es\/wp-json\/wp\/v2\/comments?post=6517"}],"version-history":[{"count":4,"href":"https:\/\/amsbiopharma.com\/es\/wp-json\/wp\/v2\/pages\/6517\/revisions"}],"predecessor-version":[{"id":6919,"href":"https:\/\/amsbiopharma.com\/es\/wp-json\/wp\/v2\/pages\/6517\/revisions\/6919"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/amsbiopharma.com\/es\/wp-json\/wp\/v2\/media\/4763"}],"wp:attachment":[{"href":"https:\/\/amsbiopharma.com\/es\/wp-json\/wp\/v2\/media?parent=6517"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}