Antibody Drug Conjugates

Antibody Drug Conjugates

Clinical efficacy of Antibody Drug Conjugates (ADC) is determined by fine-tuning combination of tumor antigen, targeting antibody, cytotoxic payload and conjugation strategy. ADC binds to tumor target cell surface antigens triggering a specific receptor mediated internalization. The internalized ADCs are decomposed to release cytotoxic payloads inside the tumor cell.

Antibody Drug Conjugates Cell cytotoxicity mechanism
Published in Avicenna Journal of Medical Biotechnology, 01 Jan 2019, 11(1):3-23

AMSbiopharma (from AMS Labs) provides a particular key characterization analysis for ADCs such as: Drug antibody ratio (DAR) and Drug conjugation size.

Moreover, as stated in the ICH guideline Q6B, AMSbiopharma provides a comprehensive catalog of services required for the characterization of a biopharmaceutical.

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